Nutritional recommendations directed toward the general population are based mainly on estimated average nutrient requirements for a target group. These norms intend both to meet the needs of most individuals in a community and to prevent common diseases, such as obesity, diabetes, and cardiovascular problems.1 Personalized nutrition guidelines are currently focused on people with metabolic disorders. Infants with inborn errors of metabolism (eg, maple syrup urine disease, phenylketonuria) or adults carrying specific genetic monogenic disorders (eg, familial hypercholesterolemia, hypolactasia) benefit from genetic-based dietary advice.