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Fiber Intake and Plasminogen Activator Inhibitor-1 in Type 2 Diabetes: Look AHEAD (Action for Health in Diabetes) Trial Findings at Baseline and Year 1
Journal of the Academy of Nutrition and Dietetics
Vol. 114Issue 11p1800–1810.e2Published online: August 15, 2014
- L. Maria Belalcazar
- Andrea M. Anderson
- Wei Lang
- Dawn C. Schwenke
- Steven M. Haffner
- Hiroshi Yatsuya
- and others
Cited in Scopus: 9
Plasminogen activator inhibitor 1 (PAI-1) is elevated in obese individuals with type 2 diabetes and may contribute, independently of traditional factors, to increased cardiovascular disease risk. Fiber intake may decrease PAI-1 levels. We examined the associations of fiber intake and its changes with PAI-1 before and during an intensive lifestyle intervention (ILI) for weight loss in 1,701 Look AHEAD (Action for Health in Diabetes) participants with dietary, fitness, and PAI-1 data at baseline and 1 year.