Main outcome measures
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Publication stageIn Press Accepted Manuscript
Contributions: VB and NJS conceptualised and designed this study; VB, QW, CM performed the data management; VB analysed and interpreted the data, with advice from CPN; VC, CPN and NJS were responsible for data acquisition; NJS acquired the financial support for the project leading to this publication; VB and NJS drafted the manuscript. All authors commented on subsequent drafts of the manuscript and critically reviewed it for important intellectual content and gave their final approval to the version to be published.
Conflict of interest: The authors report no conflict of interest in relation to this work.
Funding: This work was funded by the UK Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council and British Heart Foundation (BHF) through MRC grant MR/M012816/1. University of Leicester investigators are supported by the National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Centre (BRC-1215-20010). CPN is funded by the BHF (SP/16/4/32697).
Acknowledgement: UK Biobank received approval from the North West Centre for Research Ethics Committee (11/NW/0382). The use of data presented in this paper was approved by the Access Committee of UKB under application number 6077.
Research Question: Are dietary patterns and practices independently associated with leucocyte telomere length (LTL)?
Key Findings: Analysis of cross-sectional data from the UK Biobank suggests that adherence to “Mediterranean” or “Prudent” dietary patterns and a practice of “Eating 5-a-day” of fruit and vegetables were positively associated with LTL, whilst adherence to a “Meat intake” pattern or “Abstaining from eggs/dairy/wheat/sugar” was negatively associated with LTL, after adjustment for major lifestyle, clinical and social determinants of LTL. However, the magnitude of these associations was small and equivalent to about 1-year of age-related change in LTL.