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Diets High in Fiber and Vegetable Protein Are Associated with Low Lumbar Bone Mineral Density in Young Athletes with Oligoamenorrhea

Published:December 11, 2015DOI:https://doi.org/10.1016/j.jand.2015.10.022

      Abstract

      Background

      Associations of bone mineral density (BMD) with specific food components, including dietary fiber and isoflavones (that have a negative association with serum estrogen), are unclear and need to be determined, particularly in populations more likely to consume large amounts of these nutrients (such as young athletes).

      Objective

      To determine dietary intake of specific food components in athletes with oligoamenorrhea (OA) compared to athletes with eumenorrhea (EA) and nonathletes (NA), and associations of the dietary intake of these nutrients with lumbar spine BMD.

      Design and subjects

      This cross-sectional study evaluated 68 OA, 24 EA, and 26 NA individuals aged 14 to 23 years. Measurements included 4-day food records, a dual x-ray absorptiometry scan evaluating lumbar spine BMD and body composition, and hormone levels. Multivariate analysis was used to estimate associations of nutrients with lumbar spine BMD.

      Results

      Compared with EA and NA, OA had higher intake of fiber, phytic acid, and vegetable protein (all P values <0.0001). Intake of isoflavones, genistein, and daidzein was higher in OA than NA (P=0.003 and P=0.0002, respectively). OA had lower consumption of energy from saturated fatty acids than NA (P=0.002). After controlling for confounders such as body weight, menstrual status (indicative of estrogen status), calcium intake, and serum vitamin D (known BMD determinants), lumbar spine BMD z scores were inversely associated with dietary fiber (β=–.30; P=0.01), vegetable protein (β= –.28; P=0.02), phytic acid (β=–.27; P=0.02), genistein (β=–.25; P=0.01), and daidzein (β=–.24; P=0.01), and positively associated with percent energy from fatty acids (β=.32; P=0.0006).

      Conclusions

      Compared with EA and NA, OA had a higher dietary intake of fiber, vegetable protein, and phytic acid, which were inversely associated with lumbar spine BMD z scores. Further studies are needed to assess dietary recommendations for OA to optimize bone accrual.

      Keywords

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      Biography

      E. Barron is a graduate student intern, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      N. Cano Sokoloff is a research fellow, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      G. D. N. Maffazioli is a research fellow, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      R. Woolley is a study coordinator, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      T. M. Holmes is a bionutritionist, Harvard Catalyst Clinical Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      E. J. Anderson is clinical research center director, Harvard Catalyst Clinical Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

      Biography

      K. E. Ackerman is a sports endocrinologist, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, and Division of Sports Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA.

      Biography

      M. Misra is a pediatric endocrinologist, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, and Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston.