Abstract
Background
People with prediabetes are at increased risk for developing type 2 diabetes mellitus.
Weight reduction through lifestyle modification can significantly reduce diabetes
risk. Yet, weight loss varies among individuals and some people do not achieve clinically
meaningful weight loss after treatment.
Objective
Our aim was to evaluate the time point and threshold for achieving ≥5% weight loss
after completion of a 16-week worksite, lifestyle intervention for diabetes prevention.
Design
Weight change before and after the behavioral intervention among participants randomized
to the experimental group was examined.
Participants/setting
Individuals with prediabetes aged 18 to 65 years with a body mass index (calculated
as kg/m2) of 25 to 50 at Ohio State University were eligible.
Intervention
The 16-week, group-based intervention, adapted from the Diabetes Prevention Program,
was delivered to 32 participants in the experimental group.
Main outcome measures
Percent weight loss was assessed weekly during the intervention and at 4- and 7-month
follow-up.
Statistical analyses performed
Linear regression modeled the relationship between percent weight loss during month
1 of the intervention and percent weight loss at 4 and 7 months. Logistic regression
modeled failure to lose ≥5% weight loss at 4 and 7 months using weekly weight change
during the first month of intervention.
Results
Percent weight loss at intervention week 5 was significantly associated with percent
weight loss at 4 and 7 months (all P<0.001). Only 11.1% and 12.5% of participants who failed to achieve a 2.5% weight-loss
threshold during month 1 achieved ≥5% weight loss at months 4 and 7, respectively.
Conclusions
The first month of lifestyle treatment is a critical period for helping participants
achieve weight loss. Otherwise, individuals who fail to achieve at least 2.5% weight
loss may benefit from more intensive rescue efforts or stepped-care interventions.
Keywords
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Biography
C. K. Miller is a professor, Department of Human Sciences, Human Nutrition, Ohio State University, Columbus.
Biography
K. R. Weinhold is a graduate research assistant, Department of Human Sciences, Human Nutrition, Ohio State University, Columbus.
Biography
H. N. Nagaraja is a professor, Division of Biostatistics, College of Public Health, Ohio State University, Columbus.
Article info
Publication history
Published online: June 19, 2015
Accepted:
April 27,
2015
Received:
December 3,
2014
Footnotes
STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors.
FUNDING/SUPPORT Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award no. R34DK093907. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
ClinicalTrials.gov identifier: NCT01682954.
Identification
Copyright
© 2015 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
