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STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors.
FUNDING/SUPPORT This project was financed by the Carlos III Health Institute of the Ministry of Health of Spain (FIS: PS09/00233, PS09/01057, PS09/01972, PS09/01376, PS09/0164, PS09/01458, RETICS (RD12/0005/0004)) and the Autonomous Government of Castilla and León (SAN/1778/2009).