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Iron Status and Its Determinants in a Nationally Representative Sample of Pregnant Women

Published:January 24, 2013DOI:https://doi.org/10.1016/j.jand.2012.10.021

      Abstract

      Iron-deficiency anemia is associated with adverse neonatal health outcomes. Iron status and its determinants were assessed in a representative sample of Belgian pregnant women. Blood samples were collected and a questionnaire was completed face-to-face. Hemoglobin (Hb) and mean cell volume were measured using a Beckman Coulter Hematology Analyzer and serum ferritin (SF) and transferrin receptor (sTfr) concentrations by immunoassay. In total, 55 obstetric clinics and 1,311 pregnant women were included. Approximately 40% of third-trimester and 6% of first-trimester women had SF levels less than 15 μg/L. Approximately 21% of third-trimester and 4% of first-trimester women had anemia (Hb <110 g/L). Of the third-trimester women, 23% were iron-deficient nonanemic (SF <15 μg/L and Hb ≥110 g/L), 16% had iron-deficiency anemia (SF <15 μg/L and Hb <110 g/L), and approximately 7% had tissue iron deficiency (sTfr >8.5 mg/L). The median body iron stores were 8.1 mg/kg among first-trimester women, but only 3.6 mg/kg among third-trimester women. SF levels were significantly positively associated with age and education level, and were higher among nulliparous women and lower among North-African women. sTfr concentrations were significantly negatively associated with age and were lower among smokers, nulliparous women, and women who planned their pregnancy. Despite the fact that two thirds of Belgian pregnant women took iron-containing supplements, iron deficiency and iron-deficiency anemia were frequent in third-trimester women. The World Health Organization regards this as a moderate public health problem. National iron supplementation guidelines are needed in Belgium to optimize iron status during pregnancy.

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      Biography

      S. Vandevijvere is a research scientist, Department of Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium.

      Biography

      H. Van Oyen is an operational director, Department of Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium.

      Biography

      S. Amsalkhir is a dietitian, Department of Nuclear Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

      Biography

      R. Moreno-Reyes is a medical doctor, Department of Nuclear Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

      Biography

      E. Ines is a research scientist, Human Nutrition Laboratory, Institute of Food, Nutrition and Health, Zurich, Switzerland.

      Linked Article

      • Erratum
        Journal of the Academy of Nutrition and DieteticsVol. 113Issue 9
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          In the article “Iron Status and Its Determinants in a Nationally Representative Sample of Pregnant Women” that appeared in the May 2013 issue of the Journal of the Academy of Nutrition and Dietetics, one of the authors was misidentified. Ines Egli, PhD, was incorrectly listed as “Egli Ines, PhD” in the article byline on page 659. She was also incorrectly identified as “E. Ines” instead of “I. Egli” in the Author Information section on page 666, and her institution, ETH Zurich, was mistakenly omitted from her affiliation information.
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