Abstract
Fat-free mass depletion has been related to increased inflammatory activity and to
increased morbidity and mortality in chronic respiratory diseases. The aims of our
study were to determine the nutritional status and serum levels of adipocytokines
and inflammatory cytokines in patients with bronchiectasis of any etiology and their
relation with respiratory parameters. A cross-sectional study was designed that included
patients aged >14 years with diagnostic criteria for bronchiectasis. Anthropometric
parameters; a diet questionnaire; hand grip dynamometry; levels of leptin, adiponectin,
interleukin-6 (IL-6), tumor necrosis factor-α, and ultrasensitive C-reactive protein;
as well as respiratory parameters (ie, clinical, radiologic, and spirometric values)
were assessed. Ninety-three clinically stable patients were recruited, 43 with cystic
fibrosis, 31 with noncystic fibrosis bronchiectasis, and 19 with cystic fibrosis transmembrane
conductance regulator-related bronchiectasis. Fat-free mass depletion was present
in 31% of patients, with no differences according to the etiology of the bronchiectasis.
Correlations were found between inflammatory cytokines (ie, IL-6) and exacerbations,
bronchorrea, forced expiratory volume in 1 second, and Bhalla score. Patients with
worse respiratory disease severity, malnutrition, and diabetes had significantly higher
levels of IL-6. Adiponectin correlated significantly and positively with fat mass
and fat mass index and negatively with fat-free mass, fat-free mass index, and hand
dynamometry. Leptin correlated positively with body mass index, fat mass and fat mass
index, and negatively with fat-free mass, fat-free mass index, and dynamometry. Patients
with bronchiectasis present a high percentage of fat-free mass depletion, independent
of the etiology of the disease. The levels of inflammatory cytokines (especially IL-6)
may be useful markers of disease severity. Adiponectin levels were higher in patients
with fat-free mass depletion.
Keywords
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Biography
G. Olveira is a consultant, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
N. Colomo is a consultant, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
N. Porras is a registered dietitian, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
G. Martín-Núñez is a junior researcher, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
E. Rubio is a junior researcher, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
G. Rojo-Martínez is a senior researcher, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
F. Soriguer is chief of service, CENTRE: Endocrinology and Nutrition Service (CIBER de Diabetes y enfermedades metabólicas asociadas of the Instituto de Salud Carlos III), Carlos Haya University Hospital, Malaga, Spain.
Biography
C. Olveira is a consultant, Pneumology Service, Carlos Haya University Hospital, Malaga, Spain.
Biography
I. Gaspar is a consultant, Pneumology Service, Costa del Sol Hospital, Marbella, Spain.
Article info
Publication history
Published online: November 20, 2012
Accepted:
August 6,
2012
Footnotes
FUNDING/SUPPORT This study was partly financed by grants from NEUMOSUR (Sociedad Andaluza de Neumología y Cirugía Torácica) and CIBERDEM (CIBER de Diabetes y Enfermedades Metabólicas Asociadas).
STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors.
Identification
Copyright
© 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
