Cruciferous Vegetable Intake Is Inversely Correlated with Circulating Levels of Proinflammatory Markers in Women

Published:March 13, 2014DOI:https://doi.org/10.1016/j.jand.2013.12.019

      Abstract

      Background

      Higher intakes of cruciferous vegetables or their constituents have been shown to lower inflammation in animal studies. However, evidence for this anti-inflammatory effect of cruciferous vegetable consumption in humans is scarce.

      Objective/Design

      In this cross-sectional analysis, we evaluated associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women. Dietary intake of foods was assessed by a food frequency questionnaire.

      Results

      Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interlukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables. The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrend=0.02), and 24.68% for IL-6 (Ptrend=0.02). A similar, but less apparent, inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables. Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined.

      Conclusions

      This study suggests that the previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables.

      Keywords

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      Biography

      Y. Jiang is deputy chief, Division of Chronic Disease Control and Prevention, Changning Center for Disease Control and Prevention, Shanghai, China, and a research fellow trainee, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      S.-H. Wu is a research fellow, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      X.-O. Shu is a professor, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      W. Zheng is a professor, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      Q. Cai is an associate professor, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      X. Zhang is an assistant professor, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      G. Yang is a research associate professor, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      G. L Milne is a research associate professor, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

      Biography

      Y.-B. Xiang is a professor, Shanghai Cancer Institute, Shanghai, China.

      Biography

      Y.-T. Gao is a professor, Shanghai Cancer Institute, Shanghai, China.

      Biography

      B.-T. Ji is a staff scientist, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.