Abstract
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Academy of Nutrition and DieteticsReferences
- Nutrigenomics and personalized diets: What will they mean for food?.Annu Rev Food Sci Technol. 2011; 2: 97-123
National Human Genome Research Institute. An overview of the Human Genome Project. http://www.genome.gov/12011238. Reviewed November 8, 2012. Accessed August 26, 2013.
Broad Institute. Elephant Genome Project. http://www.broadinstitute.org/science/projects/mammals-models/elephant/elephant-genome-project. Accessed August 26, 2013.
National Human Genome Research Institute. DNA sequencing costs: Data from NHGRI Large-Scale Genome Sequencing Program (GSP): Overview. http://www.genome.gov/sequencingcosts. Updated October 29, 2013. Accessed November 18, 2013.
National Human Genome Research Institute. DNA sequencing costs: Data from NHGRI Large-Scale Genome Sequencing Program (GSP): Cost categories. http://www.genome.gov/sequencingcosts/. Updated October 29, 2013. Accessed November 18, 2013.
- Whole-genome sequencing in personalized therapeutics.Clin Pharmacol Ther. 2012; 91: 1001-1009
US National Library of Medicine. Cells and DNA. http://ghr.nlm.nih.gov/handbook/basics?show=all. November 12, 2013. Accessed November 18, 2013.
US National Library of Medicine. How genes work. http://ghr.nlm.nih.gov/handbook/howgeneswork?show=all. November 12, 2013. Accessed November 18, 2013.
- Omics technologies, data and bioinformatics principles.Methods Mol Biol. 2011; 719: 3-30
- Nutrigenetics and personalised nutrition: How far have we progressed and are we likely to get there?.Proc Nutr Soc. 2009; 68: 162-172
- Nutritional systems biology: Definitions and approaches.Annu Rev Nutr. 2009; 29: 329-339
- Nutrigenetics/nutrigenomics.Annu Rev Public Health. 2010; 31: 53-68
- Nutrigenomics in cardiovascular medicine.Circ Cardiovasc Genet. 2009; 2: 637-651
- Homocysteine and coronary heart disease: Meta-analysis of MTHFR case-control studies, avoiding publication bias.PLoS Med. 2012; 9: e1001177
- Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults.Am J Clin Nutr. 2012; 95: 1245-1253
- Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.Clin Chem Lab Med. 2012; 0: 1-9
- Nutritional genomics: Defining the dietary requirement and effects of choline.J Nutr. 2011; 141: 531-534
- Association of apolipoprotein E genotypes with lipid levels and coronary risk.JAMA. 2007; 298: 1300-1311
- Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease.Ann Intern Med. 2004; 141: 137-147
- Apolipoprotein E alleles and risk of coronary disease. A meta-analysis.Arterioscler Thromb Vasc Biol. 1996; 16: 1250-1255
- Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: The Framingham Heart Study.Circulation. 2006; 113: 2062-2070
- Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: Implications for a nutrigenetic approach.J Obes. 2011; 2011: 497401
- Gene-environment interactions in obesity.Forum Nutr. 2010; 63: 195-203
- The genetics of obesity.Curr Diab Rep. 2010; 10: 498-505
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.Science. 2007; 316: 889-894
- An obesity-associated FTO gene variant and increased energy intake in children.N Engl J Med. 2008; 359: 2558-2566
- Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment.Am J Clin Nutr. 2008; 87: 398-404
- Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: The FUNGENUT Study.Am J Clin Nutr. 2007; 85: 1417-1427
- Changes in adipose tissue gene expression with energy-restricted diets in obese women.Am J Clin Nutr. 2005; 81: 1275-1285
- Individualized weight management: What can be learned from nutrigenomics and nutrigenetics?.Prog Mol Biol Transl Sci. 2012; 108: 347-382
- Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.Proc Natl Acad Sci U S A. 2008; 105: 8369-8374
- Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation.PLoS One. 2011; 6: e24004
- Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics.Biochem Pharmacol. 2010; 80: 1771-1792
- Nutrigenetics and nutrigenomics: Viewpoints on the current status and applications in nutrition research and practice.J Nutrigenet Nutrigenomics. 2011; 4: 69-89
- Epigenetics: What it is and how it can affect dietetics practice.J Am Diet Assoc. 2008; 108: 1056-1059
- Dietary factors and epigenetic regulation for prostate cancer prevention.Adv Nutr. 2011; 2: 497-510
- Transposable elements: Targets for early nutritional effects on epigenetic gene regulation.Mol Cell Biol. 2003; 23: 5293-5300
- Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.Environ Health Perspect. 2006; 114: 567-572
- Persistent epigenetic differences associated with prenatal exposure to famine in humans.Proc Natl Acad Sci U S A. 2008; 105: 17046-17049
- The Dutch famine and its long-term consequences for adult health.Early Hum Dev. 2006; 82: 485-491
- Epigenetics and obesity.Prog Mol Biol Transl Sci. 2010; 94: 291-347
- A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss.FASEB J. 2011; 25: 1378-1389
- Parent-of-origin testing for 15q11-q13 gains by quantitative DNA methylation analysis.J Mol Diagn. 2012; 14: 192-198
- Understanding the pathogenesis of Angelman syndrome through animal models.Neural Plast. 2012; 2012: 710943
- National Institutes of Health State-of-the-Science Conference Statement: Family history and improving health.Ann Intern Med. 2009; 151: 872-877
- The family history: The first genetic test, and still useful after all those years?.Genet Med. 2012; 14: 3-9
- Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level.J Natl Cancer Inst. 2013; 105: 130-140
- Recommendations from the EGAPP Working Group: Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives.Genet Med. 2009; 11: 35-41
- Recommendations from the EGAPP Working Group: Genomic profiling to assess cardiovascular risk to improve cardiovascular health.Genet Med. 2010; 12: 839-843
- Beyond base pairs to bedside: A population perspective on how genomics can improve health.Am J Public Health. 2012; 102: 34-37
- Direct-to-Consumer Genetic Testing: Summary of a Workshop.National Academies Press, Washington, DC2010
- Familial hypercholesterolemias: Prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia.J Clin Lipidol. 2011; 5: S9-S17
Centers for Disease Control and Prevention. Genomic tests and family history by levels of evidence. http://www.cdc.gov/genomics/gtesting/tier.htm. Updated April 15, 2013. Accessed August 26, 2013.
US Preventive Servies Task Force homepage. http://www.uspreventiveservicestaskforce.org/index.html. Accessed August 26, 2013.
US Department of Health and Human Services, Secretary's Advisory Committee on Genetics, Health, and Society, US System of Oversight of Genetic Testing: A Response to the Charge of the Secretary of Health and Human Services; 2008. http://oba.od.nih.gov/oba/SACGHS/reports/SACGHS_oversight_report.pdf. Accessed December 19, 2013.
- Genetics tells tall tales.Nature. 2010; 465: 998
- Direct-to-consumer genetic testing: perceptions, problems, and policy responses.Annu Rev Med. 2012; 63: 23-33
- Direct-to-consumer genetic testing: Introduction to the Special Issue.J Genet Couns. 2012; 21: 357-360
- Negotiating the boundary between medicine and consumer culture: Online marketing of nutrigenetic tests.Soc Sci Med. 2010; 70: 744-753
- Awareness and uptake of direct-to-consumer genetic testing among cancer cases, their relatives, and controls: The Northwest Cancer Genetics Network.Genet Test Mol Biomarkers. 2012; 16: 744-748
- Direct-to-consumer genetic testing: Reliable or risky?.Clin Chem. 2011; 57: 1641-1644
- Direct-To-Consumer Genetic Tests: Misleading Test Results are Further Complicated by Deceptive Marketing and Other Questionable Practices.Government Accountability Office, Washington, DC2010: 1-33
- State of play in direct-to-consumer genetic testing for lifestyle-related diseases: Market, marketing content, user experiences and regulation.Proc Nutr Soc. 2013; 72: 53-60
- Putting together the pieces: Recent proposals to fill in the genetic testing regulatory puzzle.Ann Health Law. 2012; 21: 383-405
US Departmentt of Health and Human Services. Summary from the Molecular & Clinical Genetics Panel Meeting – March 8-9, 2011. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/MolecularandClinicalGeneticsPanel/UCM246907.pdf?utm_campaign=Google2&utm_source=fdaSearch&utm_medium=website&utm_term=geneticpanel&utm_content=3. Accessed August 26, 2013.
Code of Federal Regulations, Title 45. Public Welfare. Department of Health and Human Services. Part 46. Protection of Human Subjects; 2009. http://www.hhs.gov/ohrp/policy/ohrpregulations.pdf. Accessed December 19, 2013.
- Bioethical considerations for human nutrigenomics.Annu Rev Nutr. 2008; 28: 447-467
- The impact of genomics on public health practice: The case for change.Public Health Genomics. 2012; 15: 118-124
- Ethical and legal issues in nutritional genomics.J Am Diet Assoc. 2008; 108: 36-40
- Ethical, legal and social issues in nutrigenomics: The challenges of regulating service delivery and building health professional capacity.Mutat Res. 2007; 622: 138-143
- Incorporating human genetics into dietetics curricula remains a challenge.J Am Diet Assoc. 2005; 105: 583-588
- Continuing education needs of registered dietitians regarding nutrigenomics.J Am Diet Assoc. 2006; 106: 1242-1245
- Genetics and diet-gene interactions: Involvement, confidence and knowledge of dietitians.Br J Nutr. 2008; 99: 23-28
- Factors associated with knowledge of genetics and nutritional genomics among dietitians.J Hum Nutr Diet. 2008; 21: 547-554
- Introducing nutritional genomics teaching in undergraduate dietetic curricula.J Nutrigenet Nutrigenomics. 2011; 4: 165-172
- Personal omics profiling reveals dynamic molecular and medical phenotypes.Cell. 2012; 148: 1293-1307
- Future changes driving dietetics workforce supply and demand: Future scan 2012-2022.J Acad Nutr Diet. 2012; 112: S10-S24
- Standards of professional practice for genetic metabolic dietitians.Genet Med. 2008; 10: 290-293
- Advanced practitioners and what they do that is different, roles in genetics.Top Clni Nutr. 2009; 23: 219-230
- American Dietetic Association: Standards of Practice and Standards of Professional Performance for registered dietitians (competent, proficient, and expert) in integrative and functional medicine.J Am Diet Assoc. 2011; 111 (e901-923): 902-913
- Nutrition tailored to the individual? Not just yet—Realigning nutrigenomic science with contemporary society.J Nutrigenet Nutrigenomics. 2009; 2: 184-188
US National Library of Medicine. Genetics home reference: Glossary. http://ghr.nlm.nih.gov/glossary/browse/. Accessed July 31, 2013.
US Department of Energy. Human Genome Project information archive 1990-2003. http://www.ornl.gov/hgmis. Modified July 23, 2013. Accessed July 31, 2013.
US National Library of Medicine. Genetics home reference: MTHFR. http://ghr.nlm.nih.gov/gene/MTHFR. Reviewed July 2011. Accessed July 31, 2013.
Yang J. Human Microbiome Project: Extending the definition of what constitutes a human. National Human Genome Research Institute website. http://www.genome.gov/27549400.%20Accessed%20August%207. Published July 16, 2012. Accessed August 7, 2013.
Additional Resources
- The ethical introduction of genome-based information and technologies into public health.Public Health Genomics. 2013; 16: 100-109
- Genetic counselors: Your partners in clinical practice.Cleve Clin J Med. 2012; 79: 560-568
- Key principles and clinical applications of “next-generation” DNA sequencing.Cancer Prev Res. 2012; 5: 887-900
Kubicek S. Infographic: Epigenetics—A primer. http://images.the-scientist.com/content/images/articles/58007/epigenetics_primer.jpg. Published March 1, 2011. Accessed November 20, 2013.
Article info
Publication history
Footnotes
This Academy of Nutrition and Dietetics position was adopted by the House of Delegates Leadership Team on September 17, 2013. This position is in effect until December 31, 2016. Requests to use portions of the position must be directed to the Academy at [email protected]
Authors: Kathryn M. Camp, MS, RD, CSP, Kelly Government Solutions, Rockville, MD (Consultant to the Office of Dietary Supplements, National Institutes of Health, Bethesda, MD); Elaine Trujillo, MS, RD, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Reviewers: Sharon Denny, MS, RD (Academy Knowledge Center, Chicago, IL); Oncology dietetic practice group (DPG) (Suzanne Dixon, MPH, MS, RD, The Health Geek, LLC, Portland, OR); Dietitians in Integrative and Functional Medicine DPG (Colleen Fogarty Draper, MS, LDN, Nestlé Institute of Health Sciences, EPFL Campus, Lausanne Switzerland); Johanna T. Dwyer, DSc, RD (Tufts University, Boston, MA); Lynnette R. Ferguson, DPhil (Oxon), DSc, FNZIFST (The University of Auckland, Auckland, New Zealand); Donna A. Israel, PhD, RD, LPC, FADA (Baylor University, Waco, TX); Quality Management Committee (Barbara Kamp, MS, RD, Johnson & Wales University, Miami, FL); Mary Pat Raimondi, MS, RD (Academy Policy Initiatives & Advocacy, Washington, DC); Research DPG (Colleen Spees, PhD, MEd, RD, LD, Ohio State University, Columbus, OH); Alison Steiber, PhD, RD (Academy Research & Strategic Business Development, Chicago, IL).
Academy Positions Committee Workgroup: Linda B. Godfrey, MS, RD, SNS, LD (chair); Christine A. Rosenbloom, PhD, RD, LD, CSSD; and Tanya Agurs-Collins, PhD, RD (content advisor).
The findings and conclusions of this report do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services.
