Research Review| Volume 114, ISSUE 1, P72-85, January 2014

Diet-Induced Weight Loss: The Effect of Dietary Protein on Bone

Published:October 30, 2013DOI:


      High-protein (>30% of energy from protein or >1.2 g/kg/day) and moderately high-protein (22% to 29% of energy from protein or 1.0 to 1.2 g/kg/day) diets are popular for weight loss, but the effect of dietary protein on bone during weight loss is not well understood. Protein may help preserve bone mass during weight loss by stimulating insulin-like growth factor 1, a potent bone anabolism stimulator, and increasing intestinal calcium absorption. Protein-induced acidity is considered to have minimal effect on bone resorption in adults with normal kidney function. Both the quantity and predominant source of protein influence changes in bone with diet-induced weight loss. Higher-protein, high-dairy diets may help attenuate bone loss during weight loss.


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      M. Tang is a postdoctoral research associate, University of Colorado Denver; at the time of the study, she was a graduate student, Nutrition Science department, Purdue University, West Lafayette, IN.


      L. E. O'Connor is a research technician, Department of Nutrition Science, Purdue University, West Lafayette, IN.


      W. W. Campbell is a professor of nutrition science, Department of Nutrition Science, Purdue University, West Lafayette, IN.