Abstract
A higher body mass index is associated with exercise-related injuries and increased
risk for musculoskeletal and connective tissue disorders, which are relevant to military
personnel. Studies show the efficacy of orlistat 60 mg for promoting weight and body
fat loss in civilians; however, its efficacy among predominantly young, male soldiers
is unknown. This study's objective was to examine the effect of a 6-month, standard
education-based weight-management program with and without orlistat 60 mg on changes
in weight and body fat in overweight soldiers. Data were collected for this randomized,
controlled trial from March 2008 to November 2010 at Fort Bragg, NC. Participants
were enrolled in an education-based weight management program (n=435; 75% men) and
were randomized to placebo or orlistat 60 mg, three capsules daily with meals. All
participants were recommended to maintain a reduced-energy, low-fat diet. Among study
completers (14% retention rate; placebo n=22, orlistat n=35) members of both groups
lost significant weight from baseline (placebo −3.0±5.2 kg; orlistat −3.2±4.7 kg;
P<0.01), but only the orlistat group lost fat mass (−2.5±3.9 kg; P<0.001), whereas the placebo group lost lean mass (−1.4±2.7 kg; P <0.01). An intent-to-treat analysis (≥1 follow-up body weight measure) demonstrated
that the orlistat group lost more fat mass vs the placebo group (−1.3±2.9 kg vs −0.6±1.8
kg, respectively; P<0.05), but less lean mass (−0.2±2.0 kg vs −0.8±1.8 kg, respectively; P<0.01). Orlistat 60 mg may be an effective adjunct to an education-based weight management
program in a mostly young, male soldier population.
Keywords
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Biography
T. J. Smith is a research dietitian, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
A. Crombie is a research dietitian, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
S. McGraw is a research nutritionist, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
A. J. Young is the division chief, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
G. P. Bathalon is the commander, US Army Research Institute of Environmental Medicine, Natick, MA; at the time of the study, he was a research dietitian, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
L. F. Sanders is chief, Nutrition Care, William Beaumont Army Medical Center, El Paso, TX; at the time of the study, she was a research dietitian, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Biography
L. D. Sigrist is director, Graduate Program in Nutrition, Fort Sam Houston, TX; at the time of the study, she was a research dietitian, Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Article info
Publication history
Published online: February 02, 2012
Accepted:
September 29,
2011
Footnotes
STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors.
Available online 2 February 2012
Identification
Copyright
Published by Elsevier Inc.
