Dietary Intakes Associated with Successful Weight Loss and Maintenance during the Weight Loss Maintenance Trial



      Dietary components effective in weight maintenance efforts have not been adequately identified.


      To determine the effects of changes in dietary consumption on weight loss and maintenance during the Weight Loss Maintenance clinical trial.


      Weight Loss Maintenance was a randomized controlled trial. Successful weight loss participants who completed Phase I of the trial and lost 4 kg were randomized to one of three maintenance intervention arms in Phase II and followed for an additional 30 months.


      The multicenter trial was conducted from 2003 through 2007. This substudy included 828 successful weight loss participants.


      The Block Food Frequency Questionnaire (FFQ) was used to assess nutrient intake levels and food group servings. Carbohydrates, proteins, fats, dietary fiber, fruit/vegetable, and dairy servings were utilized as predictor variables. The FFQ was collected on all participants at study entry (beginning of Phase I). Those randomized to Phase II completed the FFQ at three additional time points: randomization (beginning of Phase II), 12 months, and 30 months.


      The main intervention focused on long-term maintenance of weight loss using the Dietary Approaches to Hypertension diet. This substudy examined if changes to specific dietary variables were associated with weight loss and maintenance.

      Statistical analyses performed

      Linear regression models that adjusted for change in total energy examined the relationship between changes in dietary intake and weight for each time period. Site, age, race, sex, and a race–sex interaction were included as covariates.


      Participants who substituted protein for fat lost, on average, 0.33 kg per 6 months during Phase I (P<0.0001) and 0.07 kg per 6 months during Phase II (P<0.0001) per 1% increase in protein. Increased intake of fruits and vegetables was associated with weight loss in Phases I and II: 0.29 kg per 6 months (P<0.0001) and 0.04 kg per 6 months (P=0.0062), respectively, per 1-serving increase. Substitution of carbohydrates for fat and protein for carbohydrates were associated with weight loss during both phases. Increasing dairy intake was associated with significant weight loss during Phase II (−0.17 kg per 6 months per 1-serving increase, P=0.0002), but not during Phase I. Dietary fiber revealed no significant findings.


      Increasing fruits, vegetables, and low-fat dairy may help achieve weight loss and maintenance.
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      C. M. Champagne is a professor, Pennington Biomedical Research Center, Baton Rouge, LA.


      S. T. Broyles is an assistant professor, Pennington Biomedical Research Center, Baton Rouge, LA.


      K. C. Cash is a research dietitian/interventionist, Pennington Biomedical Research Center, Baton Rouge, LA.


      E. J. Levy is a research dietitian/interventionist, Pennington Biomedical Research Center, Baton Rouge, LA.


      V. H. Myers is an instructor, Pennington Biomedical Research Center, Baton Rouge, LA.


      L. D. Moran is a clinical dietitian, Baton Rouge Clinic, Baton Rouge, LA.


      P.-H. Lin is an associate research professor, Department of Medicine, Nephrology Division, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.


      B. C. Batch is with the Department of Medicine, Endocrinology, Metabolism, and Nutrition Division, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.


      L. F. Lien is medical director, Duke Inpatient Diabetes Management, and an assistant professor, Department of Medicine, Endocrinology, Metabolism, and Nutrition Division, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.


      K. L. Funk is a research associate III, Kaiser Permanente Center for Health Research, Portland, OR.


      A. Dalcin is a research associate, Johns Hopkins ProHealth, Baltimore, MD.


      C. Loria is a nutritional epidemiologist, Division of Cardiovascular Services, National Heart, Lung, and Blood Institute, Bethesda, MD.