Advertisement

A Novel Dietary Intervention to Optimize Vitamin E Intake of Pregnant Women to 15 mg/Day

Published:December 19, 2011DOI:https://doi.org/10.1016/j.jada.2011.08.033

      Abstract

      Associations have been reported between suboptimal maternal vitamin E intake during pregnancy and childhood asthma. This pilot study conducted in 2008/2009 investigated the feasibility and acceptability of a food-based randomized controlled trial in pregnant women to optimize dietary vitamin E intake to 15 mg/day. A food-based intervention using “food exchanges” to individually optimize dietary vitamin E intake to 15 mg/day was developed and included in an advice booklet. Forty-three pregnant women with a personal/partner history of asthma were recruited at 12 weeks gestation and randomized to food-based intervention or a control group until 20 weeks gestation. A registered dietitian assessed the vitamin E intake of 22 women and provided tailored advice on food-based exchanges to optimize their intake to 15 mg/day. The 21 control women were not given dietary advice. The food-based intervention was completed by 19 women and increased mean vitamin E intake: food diary data, 7.13 mg/day (95% confidence interval: 5.63 to 18.6) to 17.4 mg/day (95% confidence interval: 14.4 to 20.5) (P<0.001). This pilot study demonstrates the feasibility and acceptability of a food-exchange−based intervention to optimize dietary vitamin E intake during pregnancy. Additional work is required to determine whether this intervention, if sustained for the rest of pregnancy, reduces the likelihood of childhood asthma. The methodology used in the design of this novel food-based intervention could be transferred to other nutrients.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Academy of Nutrition and Dietetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • McNeill G.
        • Tagiyeva N.
        • Aucott L.
        • Russell G.
        • Helms P.J.
        Changes in the prevalence of asthma, eczema and hay fever in pre-pubertal children: A 40-year perspective.
        Paediatr Perinatal Epidemiol. 2009; 23: 506-512
        • Seaton A.
        • Godden D.J.
        • Brown K.M.
        Increase in asthma: A more toxic environment or a more susceptible population?.
        Thorax. 1994; 49: 171-174
        • Nurmatov U.
        • Devereux G.
        • Sheikh A.
        Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis.
        J Allergy Clin Immunol. 2011; 127: 724-733
        • Lawlor D.A.
        • Davey Smith G.
        • Kundu D.
        • Bruckdorfer K.R.
        • Ebrahim S.
        Those confounded vitamins: What can we learn from the differences between observational versus randomized trial evidence?.
        Lancet. 2004; 363: 1724-1727
        • Greenough A.
        • Shaheen S.O.
        • Shennan A.
        • Seed P.T.
        • Poston L.
        Respiratory outcomes in early childhood following antenatal vitamin C and E supplementation.
        Thorax. 2010; (998-1003): 65
        • Institute of Medicine, Food and Nutrition Board
        Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium and Carotenoids.
        National Academies Press, Washington, DC2000 (Posted 2003. Accessed March 2010)
        • Masson L.F.
        • McNeill G.
        • Tomany J.O.
        • et al.
        Statistical approaches for assessing the relative validity of a semi-quantitative food frequency questionnaire: Use of correlation coefficients and the Kappa statistic.
        Public Health Nutr. 2003; 6: 313-321
        • Martindale S.
        • McNeill G.
        • Devereux G.
        • Campbell D.
        • Russell G.
        • Seaton A.
        Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life.
        Am J Respir Crit Care Med. 2005; 171: 121-128
        • Devereux G.
        • Turner S.W.
        • Craig L.C.A.
        • et al.
        Reduced maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children.
        Am J Respir Crit Care Med. 2006; 174: 499-507
        • Scottish Government
        Scottish Index of Multiple Deprivation.
        (Accessed December 2010)
        • Litonjua A.A.
        • Rifas-Shiman S.L.
        • Ly N.P.
        • et al.
        Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age.
        Am J Clin Nutr. 2006; 84: 903-911
        • Olsen S.F.
        • Osterdal M.L.
        • Salvig J.D.
        • et al.
        Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial.
        Am J Clin Nutr. 2008; 88: 167-175
        • Shaheen S.O.
        • Newson R.B.
        • Henderson A.J.
        • Emmett P.M.
        • Sherriff A.
        • Cooke M.
        Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema.
        Eur Respir J. 2004; 24: 292-297
        • Tricon S.
        • Willers S.
        • Smit H.A.
        • et al.
        Nutrition and allergic disease.
        Clin Exp Allergy Rev. 2006; 6: 117-188
        • Devereux G.
        • McNeill G.
        • Newman G.
        • et al.
        Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates.
        Clin Exp Allergy. 2007; 37: 1000-1008
        • Sala-Vila A.
        • Miles E.A.
        • Calder P.C.
        Fatty acid composition abnormalities in atopic disease: Evidence explored and role in the disease process examined.
        Clin Exp Allergy. 2008; 38: 1432-1450
        • Scaife A.R.
        • McNeill G.
        • Campbell D.M.
        • Martindale S.
        • Devereux G.
        • Seaton A.
        Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery.
        Br J Nutr. 2006; 95: 771-778
        • Gibson R.S.
        Principles of Nutritional Assessment.
        2nd ed. Oxford University Press, New York, NY2005
        • Poston L.
        • Briley A.L.
        • Seed P.T.
        • Kelly F.J.
        • Shennan A.H.
        Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): Randomised placebo-controlled trial.
        Lancet. 2006; 367: 1145-1154
        • Sawada S.
        • Tamai H.
        • Mino M.
        Vitamin E status of pregnant women with respect to platelet and buccal mucosal cell tocopherol levels.
        Pathophysiology. 1994; 1: 69-72

      Biography

      J. Clark is a research dietitian, Public Health Nutrition Research Group, University of Aberdeen, Aberdeen, UK

      Biography

      L. Craig is a research fellow, Public Health Nutrition Research Group, University of Aberdeen, Aberdeen, UK

      Biography

      G. McNeill is a professor of public health nutrition, University of Aberdeen, Aberdeen, UK

      Biography

      G. Devereux is a professor of respiratory medicine and an honorary consultant physician, University of Aberdeen, Aberdeen, UK

      Biography

      N. Smith is a consultant obstetrician, Aberdeen Maternity Hospital, Aberdeen, UK

      Biography

      J. Norrie is a professor of clinical trials and biostatistics, University of Glasgow, Glasgow, UK