Abstract
Green tea catechins (GTCs) have been studied in randomized control trials for their
lipid-lowering effects. Studies, however, have been small and demonstrated conflicting
results. The objective of this study was to perform a systematic review and meta-analysis
of randomized controlled trials evaluating the relationship between GTCs and serum
lipid levels, including total, low-density lipoprotein (LDL), high-density lipoprotein
(HDL) cholesterol, and triglycerides. A systematic literature search of MEDLINE, EMBASE,
Cochrane CENTRAL, and the Natural Medicines Comprehensive Database was conducted through
March 2010. Randomized controlled trials evaluating GTCs vs control in human beings
and reporting efficacy data on at least one of the aforementioned serum lipid endpoints
were included. Weighted mean differences for changes from baseline (with 95% confidence
intervals [CIs]) for lipid endpoints were calculated using random-effects models.
Twenty trials (N=1,415) met all inclusion criteria. Upon meta-analysis, GTCs at doses
ranging from 145 to 3,000 mg/day taken for 3 to 24 weeks reduced total (−5.46 mg/dL
[−0.14 mmol/L]; 95% CI −9.59 to −1.32) and LDL cholesterol (−5.30 mg/dL [−0.14 mmol/L];
95% CI −9.99 to −0.62) compared to control. GTCs did not significantly alter HDL cholesterol
(−0.27 mg/dL [−0.007 mmol/L]; 95% CI −1.62 to 1.09) or triglyceride (3.00 mg/dL [−0.034
mmol/L]; 95% CI −2.73 to 8.73) levels. The consumption of GTCs is associated with
a statistically significant reduction in total and LDL cholesterol levels; however,
there was no significant effect on HDL cholesterol or triglyceride levels.
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Biography
A. Kim is a pharmacy practice resident, University of Connecticut School of Pharmacy, Hartford, CA.
Biography
A. Chiu is a research scientist, University of Connecticut School of Pharmacy, Hartford, CA.
Biography
M. K. Barone is a research scientist, University of Connecticut School of Pharmacy, Hartford, CA.
Biography
F. Wang is an associate clinical professor of pharmacy practice, University of Connecticut School of Pharmacy, Hartford, CA.
Biography
C. I. Coleman is an associate professor of pharmacy practice, University of Connecticut School of Pharmacy, Hartford, CA.
Biography
O. J. Phung is an assistant professor of pharmacy practice, College of Pharmacy, Western University of Health Sciences, Pomona, CA.
Article info
Publication history
Accepted:
May 5,
2011
Identification
Copyright
© 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
