Abstract
Many elderly people have a low intake of dietary protein, yet their protein requirement
may be higher than the current Recommended Dietary Allowance. High-quality protein
supplements may be useful to enhance nitrogen retention and increase the availability
of essential amino acids in elderly people. We compared the nitrogen balance of two
protein supplements (Resource Beneprotein Instant Protein Powder, Nestlé HealthCare
Nutrition, Minnetonka, MN, a whey protein concentrate; or Pro-Stat 101, Medical Nutrition
USA, Englewood, NJ, a concentrated, fortified, collagen protein hydrolysate) varying
in type but not amount of protein content using a crossover study design. The study
consisted of two 15-day diet trials separated by a ≥1-week washout period. Nine healthy
elderly women (age 71±1 years) were provided a eucaloric diet containing approximately
the protein Recommended Dietary Allowance of 0.8 g/kg body weight/day. The supplements
constituted about half of the total protein provided to each subject. Nitrogen balance
responses were assessed over days 6 to 10 and days 11 to 14 of each trial. Measured
nitrogen content of the foods indicated that subjects consumed 0.81±0.02 g protein/kg/day
and 0.85±0.05 g/kg/day for the whey and fortified collagen protein trials, respectively.
Body weight decreased (P=0.02) after consumption of the whey supplement, with no significant changes in body
weight or composition resulting from the consumption of the collagen supplement. Nitrogen
excretion was higher during the whey supplement trial than during the collagen trial
(P=0.047). Therefore, a concentrated, fortified, hydrolyzed collagen protein supplement
maintained nitrogen balance and preserved lean body mass during 15 days of consumption
of a relatively low-protein diet.
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References
- What is sarcopenia?.J Gerontol A Biol Sci Med Sci. 1995; 50: 5-8
- Functional and metabolic consequences of sarcopenia.J Nutr. 1997; 127: 998S-1003S
- Protein requirements of elderly people.Eur J Clin Nutr. 1996; 50: S180-S183
- Increased protein requirements in the elderly: New data and retrospective reassessments.Am J Clin Nutr. 1994; 60: 167-175
- Protein and amino acid requirements in the elderly.Eur J Clin Nutr. 2000; 54: S131-S142
- The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle.J Gerontol A Biol Sci Med Sci. 2001; 56: M373-M380
- Dietary intake of elderly living in Toronto long-term care facilities: Comparison to the dietary reference intake.Rejuvenation Res. 2007; 10: 301-309
- Current protein intake in America: Analysis of the National Health and Nutrition Examination Survey, 2003-2004.Am J Clin Nutr. 2008; 87: 1554S-1557S
- Protein turnover and energy metabolism of elderly women fed a low-protein diet.Am J Clin Nutr. 1995; 62: 40-48
- Meta-analysis: Protein and energy supplementation in older people.Ann Intern Med. 2006; 144: 37-48
- Modular protein supplements and their application to long-term care.Nutr Clin Pract. 2006; 21: 485-504
- A Biometric Study of Basal Metabolism in Man.Carnegie Institute Publishers, Washington, DC1919
- Sweat and miscellaneous nitrogen losses in human balance studies.J Nutr. 1971; 101: 775-786
- Body composition by air-displacement plethysmography by using predicted and measured thoracic gas volumes.J Appl Physiol. 1998; 84: 1475-1479
- Body composition from fluid spaces and density: Analysis of methods.in: Brozek J. Henschel A. Techniques for Measuring Body Composition. National Academies Press, Washington, DC1961: 223-244
- Energy and Protein Requirements. World Health Organization, Geneva, Switzerland1985 (Technical Report Series 724)
- Protein requirements of elderly women: Nitrogen balance responses to three levels of protein intake.J Gerontol A Biol Sci Med Sci. 2001; 56A: M724-M730
- Criteria for valid nitrogen balance measurement of protein requirements.Eur J Clin Nutr. 1996; 50: S196-S197
- Dietary protein adequacy and lower body vs whole body resistive training in older humans.J Physiol. 2002; 542: 631-642
- Effects of resistance training and dietary protein intake on protein metabolism in older adults.Am J Physiol. 1995; 268: E1143-E1153
- Dietary protein requirements and body protein metabolism in endurance-trained men.J Appl Physiol. 1989; 66: 2850-2856
- Body-composition assessment via air-displacement plethysmography in adults and children: A review.Am J Clin Nutr. 2002; 75: 453-467
Walters SJ. Consultant's forum: Should post hoc sample size calculations be done? Pharm Stat. April 17, 2008 e-publication. http://www3.interscience.wiley.com/journal/118639783/abstract. Accessed April 10, 2009.
- The value of a post hoc power analysis.J Bone Joint Surg Am. 2002; 84 ([letter to the Editor]): 1272
- Human protein requirements: Assessment of the adequacy of the current Recommended Dietary Allowance for dietary protein in elderly men and women.Am J Clin Nutr. 1982; 35: 6-14
- Comparative nitrogen balance study between young and aged adults using three levels of protein intake from a combination wheat-soy-milk mixture.Am J Clin Nutr. 1978; 31: 12-22
- Human protein requirements: nitrogen balance response to graded levels of egg protein in elderly men and women.Am J Clin Nutr. 1978; 31: 779-785
- Protein requirements of elderly men.J Nutr. 1979; 109: 513-524
- Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response.Am J Clin Nutr. 1995; 62: 30-39
- Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial.Adv Skin Wound Care. 2006; 19: 92-96
- The metabolic response to two very low energy diets (VLED) of differing amino acid composition during weight reduction.Int J Obes Relat Metab Disord. 1992; 16: 1005-1012
- Regulation of protein metabolism in relation to adequacy of intake.Infusionsther Klin Ernahr. 1975; 2: 112-117
- Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids.Am J Clin Nutr. 2005; 82: 1065-1073
Biography
N. P. Hays is a research assistant professor, Donald W. Reynolds Department of Geriatrics, College of Medicine, and an assistant professor, Department of Dietetics and Nutrition, College of Health Related Professions, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock.
Biography
W. J. Evans is a professor and Warmack chair, Donald W. Reynolds Department of Geriatrics, College of Medicine, and a professor, Department of Dietetics and Nutrition, College of Health Related Professions, University of Arkansas for Medical Sciences, Little Rock.
Biography
O. Kajkenova is an assistant professor, Donald W. Reynolds Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock.
Biography
H. Kim is a graduate research assistant, Department of Dietetics and Nutrition, College of Health Related Professions, University of Arkansas for Medical Sciences, Little Rock.
Biography
A. M. Wells is a research dietitian, Clinical Research Center, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock.
Article info
Publication history
Accepted:
October 3,
2008
Identification
Copyright
© 2009 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
