Abstract
An increasing body of evidence points to a role for vitamin K in brain physiology
through its participation in sphingolipid metabolism and biological activation of
the vitamin K–dependent protein Gas6. One hypothesis is that vitamin K may also play
a role in the pathogenesis of Alzheimer's disease. A recent study found that patients
with early-stage Alzheimer's disease consumed less vitamin K than did cognitively
intact control subjects. To learn more about the dietary intakes and food sources
of vitamin K in these patients, a detailed analysis was conducted. Dietary vitamin
K intakes were assessed from 5 nonconsecutive days of food records collected from
31 community-dwelling patients with early-stage Alzheimer's disease and in 31 age-
and sex-matched cognitively intact control subjects. Mean vitamin K intake on a person-day
basis was 63±90 μg/day in patients and 139±233 μg/day in control subjects. Vitamin
K intakes were significantly less in participants with Alzheimer's disease (P<0.0001), even after adjusting for energy intakes (P=0.0003). Vegetables, fats, and fruits contributed more than 70% of total vitamin
K intake in both groups. The main source of vitamin K was green vegetables, which
contributed 33% and 49% to total intakes in patients and control subjects, respectively.
This lower consumption of green vegetables in participants with Alzheimer's disease
explained their lower vitamin K intakes overall. Despite their limitations, results
are in line with the most recent research in both vitamin K and Alzheimer's disease
and suggest a need to consider vitamin K in future investigations on the role of diet
in Alzheimer's disease.
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References
- Vitamin K.in: Bowman B.A. Russell R.M. Present Knowledge in Nutrition. 9th ed. ILSI Press, Washington, DC2006: 220-230
- Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain.J Nutr. 2004; 134: 167-172
- Vitamin K and sphingolipid metabolism: Evidence to date.Nutr Rev. 2005; 63: 111-121
- The possible role of vitamin K deficiency in the pathogenesis of Alzheimer's disease and in augmenting brain damage associated with cardiovascular disease.Med Hypotheses. 2001; 57: 151-155
- Pathways towards and away from Alzheimer's disease.Nature. 2004; 430: 631-639
- Gas6 rescues cortical neurons from amyloid β protein-induced apoptosis.Neuropharmacology. 2002; 43: 1289-1296
- Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease.Curr Alzheimer Res. 2005; 2: 65-77
- Poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage Alzheimer dementia compared to cognitively intact matched controls.J Am Diet Assoc. 2007; 107: 2091-2099
- Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women.Eur J Clin Nutr. 1995; 49: 832-841
- Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: Data from the FDA Total Diet Study.J Am Diet Assoc. 1996; 96: 149-154
- Intake and sources of phylloquinone (vitamin K1): Variation with socio-demographic and lifestyle factors in a national sample of British elderly people.Br J Nutr. 2002; 87: 605-613
- Relationships between dietary intakes and fasting plasma concentrations of fat-soluble vitamins in humans.J Nutr. 1997; 127: 587-592
- Composition of foods raw, processed, prepared—USDA Nutrient Database for Standard Reference, Release 16-1; issued March 2004.(Accessed May 22, 2004)
- Use of BMI in the assessment of undernutrition in older subjects: Reflecting on practice.Proc Nutr Soc. 2005; 64: 313-317
- The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: Relationship to episodic and semantic memory impairment.Neuropsychologia. 2000; 38: 252-271
- Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease.Arch Phys Med Rehabil. 2005; 86: 576-581
- Mediterranean diet and cardiovascular disease: Is there a role for vitamin K?.FASEB J. 2001; 15: 394
- Mediterranean diet and risk for Alzheimer's disease.Ann Neurol. 2006; 59: 912-921
- Fruit and vegetable consumption and cognitive decline in aging women.Ann Neurol. 2005; 57: 713-720
- Associations of vegetable and fruit consumption with age-related cognitive change.Neurology. 2006; 67: 1370-1376
- Dietary phylloquinone depletion and repletion in older women.J Nutr. 2003; 133: 2565-2569
- Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition.Ann NY Acad Sci. 2002; 977: 155-161
- Taste and smell perception in the elderly: Effect of medications and disease.Adv Food Nutr Res. 2002; 44: 247-346
- Depression in Alzheimer's disease: Heterogeneity and related issues.Biol Psychiatry. 2003; 54: 353-362
- Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain.J Nutr Health Aging. 2006; 10: 377-385
Biography
N. Presse is a dietitian, Centre de recherche, Institut universitaire de gériatrie de Montréal (CRIUGM) and doctoral student, Département de nutrition, Université de Montréal, Montréal, Canada
Biography
B. Shatenstein is an associate professor, Département de nutrition, Université de Montréal, and a scientist at CRIUGM, Montréal, Canada
Biography
M.-J. Kergoat is associate professor, Faculté de médecine, Université de Montréal, head, Département de médecine spécialisée, Institut universitaire de gériatrie de Montréal, and a scientist at CRIUGM, Montréal, Canada
Biography
G. Ferland is a full professor, Département de nutrition, Université de Montréal, and a scientist at CRIUGM, Montréal, Canada
Article info
Publication history
Accepted:
May 23,
2008
Identification
Copyright
© 2008 American Dietetic Association. Published by Elsevier Inc. All rights reserved.