Advertisement
Research Research and Professional Brief| Volume 108, ISSUE 10, P1693-1699, October 2008

Download started.

Ok

Low Docosahexaenoic Acid in the Diet and Milk of Women in New Mexico

      Abstract

      Because docosahexaenoic acid (DHA) is critical for the development of the nervous system, especially during the first year of life, the content of DHA in human milk is important for the well-being of exclusively breastfed infants. The aim of this study was to determine the fatty acid composition, including DHA, of the breast milk fat and serum phospholipids of women in New Mexico, and to correlate these data with dietary fatty acid content. Samples of blood and breast milk, 3-day diet records, and information on dietary supplement use were obtained from 29 women. Eligible subjects were nonsmokers, aged 18 to 40 years, lactating for 1 to 6 months, and not pregnant, taking immunosuppressive drugs, or diagnosed with diabetes. The mean fat content of the breast milk was 3.37±2.34 g/dL. The percentage of DHA in the milk fat was very low (0.11%) relative to international norms (0.2% to 0.4%) and could be explained by the women's low intake of DHA (33 to 58 mg/day). These data can be explained by the fact that the subjects were not taking DHA supplements or consuming foods that are good sources of DHA. Correlations were found between the percentages of DHA in the serum phospholipids and milk fat. The findings underscore the need for educating lactating women about food sources of DHA. Educational opportunities could occur in conjunction with other education postdelivery or during postnatal clinic visits.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Academy of Nutrition and Dietetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kurlak L.O.
        • Stephenson T.J.
        Plausible explanations for effects of long-chain polyunsaturated fatty acids (LCPUFA) on neonates.
        Arch Dis Child. 1999; 80: F148-F154
        • Lauritzen L.
        • Hansen H.S.
        • Jorgensen M.H.
        • Michaelsen K.F.
        The essentiality of long-chain polyunsaturated fatty acids in relation to development and function of the brain and retina.
        Prog Lipid Res. 2001; 40: 1-94
        • Dunstan J.A.
        • Mitoulas L.R.
        • Dixon G.
        • Doherty D.A.
        • Hartmann P.E.
        • Simmer K.
        • Prescott S.L.
        The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: A randomized, controlled trial.
        Pediatr Res. 2007; 62: 689-694
        • Bouwstra H.
        • Dijck-Brouwer D.A.
        • Wildeman J.A.
        • Tjoonk H.M.
        • van der Heide J.C.
        • Boersma E.R.
        • Muskeit F.A.
        • Hadders-Algra M.
        Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants.
        Am J Clin Nutr. 2003; 78: 313-318
        • Uauy R.
        • Hoffman D.R.
        • Mena P.
        • Llanos A.
        • Birch E.E.
        Term infant studies of DHA and ARA supplementation on neurodevelopment: Results of randomized controlled trials.
        J Pediatr. 2003; 143: S17-S25
        • Hoffman D.R.
        • Theuer R.C.
        • Castaneda Y.S.
        • Wheaton D.H.
        • Bosworth R.G.
        • O'Connor A.R.
        • Morale S.E.
        • Weidemann L.E.
        • Birch E.E.
        Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk.
        J Nutr. 2004; 134: 2307-2313
        • Cohen J.T.
        • Bellinger D.C.
        • Connor W.E.
        • Shaywitz B.A.
        A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development.
        Am J Prev Med. 2005; 29: 366-374
        • Groh-Wargo S.
        • Jacobs J.
        • Auestad N.
        • O'Connor D.L.
        • Moore J.J.
        • Lerner E.
        Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: A prospective, randomized, controlled trial.
        Pediatr Res. 2005; 57: 712-718
        • Jensen C.L.
        • Voigt R.G.
        • Prager T.C.
        • Zou Y.L.
        • Fraley J.K.
        • Rozelle J.C.
        • Turcich M.R.
        • Llorente A.M.
        • Anderson R.E.
        • Heird W.C.
        Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants.
        Am J Clin Nutr. 2005; 82: 125-132
        • Lauritzen L.
        • Hoppe C.
        • Straarup E.M.
        • Michaelsen K.F.
        Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life.
        Pediatr Res. 2005; 58: 235-242
        • Harris W.S.
        • Connor W.E.
        • Lindsey S.
        Will dietary omega-3 fatty acids change the composition of human milk?.
        Am J Clin Nutr. 1984; 40: 780-785
        • Jensen C.L.
        • Maude M.
        • Anderson R.E.
        • Heird W.C.
        Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids.
        Am J Clin Nutr. 2000; 71: 292S-299S
        • Francois C.A.
        • Connor S.L.
        • Wander R.C.
        • Connor W.E.
        Acute effects of dietary fatty acids on the fatty acids of human milk.
        Am J Clin Nutr. 1998; 67: 301-308
        • Holmer G.
        Biochemistry of trans monoenoic fatty acids.
        in: Sebedio J.L. Christie W.W. Trans Fatty Acids in Human Nutrition. The Oily Press, Dundee, UK1998: 163-189
        • Brenna J.T.
        • Varamini B.
        • Jensen R.G.
        • Diersen-Schade D.A.
        • Boettcher J.A.
        • Arterburn L.M.
        Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide.
        Am J Clin Nutr. 2007; 85: 1457-1464
      1. (New Mexico Breastfeeding Task Force Web site) (Accessed October 8, 2007)
        • Pareo-Tubbeh S.L.
        • Romero L.J.
        • Baumgartner R.N.
        • Garry P.J.
        • Lindeman R.D.
        • Koehler K.M.
        Comparison of energy and nutrient sources of elderly Hispanics and non-Hispanic whites in New Mexico.
        J Am Diet Assoc. 1999; 99: 572-582
        • Imm P.
        • Knobeloch L.
        • Anderson H.A.
        Maternal recall of children's consumption of commercial and sport-caught fish: Findings from a multistate study.
        Environ Res. 2007; 103: 198-204
        • Neville M.C.
        Sampling and storage of human milk.
        in: Jensen R.G. Handbook of Milk Composition. Academic Press, San Diego, CA1995: 70
        • Thompson F.E.
        • Byers T.
        Dietary assessment resource manual.
        J Nutr. 1994; 124: 2245S-2317S
        • Thomson C.
        • Bloch A.S.
        • Hasler C.M.
        Position of The American Dietetic Association: Functional foods.
        J Am Diet Assoc. 1999; 99: 1278-1285
        • Gordon C.C.
        • Chumlea W.C.
        • Roche A.F.
        Stature, recumbent length and weight.
        in: Lohman T.G. Roche A.F. Martorell R. Anthropometric Standardization Reference Manual. Human Kinetics Books, Champaign, IL1988: 3-8
      2. What you need to know about mercury in fish and shellfish.
        (US Environmental Protection Agency Web site) (Accessed October 25, 2006)
        • Moschidis M.C.
        • Demopoulos C.A.
        • Kritikou L.G.
        Isolation of hen's egg phosphonolipids by thin-layer chromatography, their identification and silicic acid column chromatographic separation.
        J Chromatog. 1984; 292: 473-478
        • Park P.
        • Goins R.
        In situ preparation of fatty acid methyl esters for analysis of fatty acid composition in foods.
        J Food Sci. 1994; 59: 1262-1266
        • Loor J.J.
        • Herbein J.H.
        Reduced fatty acid synthesis and desaturation due to exogenous trans 10, cis 12-CLA in cows fed oleic or linoleic oil.
        J Dairy Sci. 2003; 86: 1354-1369
      3. Guidelines on overweight and obesity, Table IV-2: Classification of overweight and obesity by BMI, waist circumference, and associated disease risk.
        (National Heart, Lung and Blood Institute Web site) (Accessed July 23, 2008)
        • Institutes of Medicine of the National Academies
        Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids.
        The National Academies Press, Washington, DC2005 (422, 1325)
        • Simopoulos A.P.
        • Leaf A.
        • Salem Jr, N.
        Workshop on the essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids.
        J Am Coll Nutr. 1999; 18: 487-489
        • Laidlaw M.
        • Holub B.J.
        Effects of supplementation with fish oil-derived n-3 fatty acids and γ-linolenic acid on circulating plasma lipids and fatty acid profiles in women.
        Am J Clin Nutr. 2003; 77: 37-42
      4. (Essential Fatty Acid Education Web site) (Accessed July 23, 2008)
        • Arterburn L.M.
        • Hall E.B.
        • Oken H.
        Distribution, interconversion, and dose response of n-3 fatty acids in humans.
        Am J Clin Nutr. 2006; 83: 1467S-1476S
        • Ambring A.
        • Johansson M.
        • Axelsen M.
        • Gan G.
        • Strandvik B.
        • Friberg P.
        Mediterranean-inspired diet lowers the ratio of serum phospholipids n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects.
        Am J Clin Nutr. 2006; 83: 575-581
        • Akabas S.R.
        • Deckelbaum R.J.
        Summary of a workshop on n-3 fatty acids: Current status of recommendations and future directions.
        Am J Clin Nutr. 2006; 83: 1536S-1538S
        • Gibson R.A.
        • Neumann M.A.
        • Makrides M.
        Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipids fatty acids and neural indices of exclusively breast fed infants.
        Eur J Clin Nutr. 1997; 51: 578-584
        • Monsen E.R.
        • Van Horn L.
        Research Successful Approaches.
        3rd ed. American Dietietic Association, Chicago, IL2008 (189)
        • US Department of Agriculture, Agricultural Research Service
        USDA National Nutrient Database for Standard Reference, release 19.
        (Nutrient Data Laboratory home page) (Accessed April 12, 2007)
      5. (ExpectaLipil Web site) (Accessed April 12, 2007)

      Biography

      R. H. Glew is a professor and D. J. VanderJagt is a research associate professor, Department of Biochemistry and Molecular Biology, and R. S. Wold is nutrition research manager, General Clinical Research Center, University of New Mexico, Albuquerque

      Biography

      J. H. Herbein is a professor, and W. A. Wark is a laboratory specialist, Department of Dairy Science, Virginia Polytechnical Institute and State University, Blacksburg

      Biography

      M. A. Martinez is a member of the faculty, Department of Nutrition, Central New Mexico Community College, Albuquerque; at the time of the study, she was a senior research nutritionist, General Clinical Research Center, University of New Mexico, Albuquerque