Algal-Oil Capsules and Cooked Salmon: Nutritionally Equivalent Sources of Docosahexaenoic Acid


      Food and nutrition professionals question whether supplement-sourced nutrients appear to be equivalent to those derived from natural food sources. We compared the nutritional availability of docosahexaenoic acid (DHA) from algal-oil capsules to that from assayed cooked salmon in 32 healthy men and women, ages 20 to 65 years, in a randomized, open-label, parallel-group study. In this 2-week study comparing 600 mg DHA/day from algal-oil capsules to that from assayed portions of cooked salmon, mean change from baseline in plasma phospholipids and erythrocyte DHA levels was analyzed and DHA levels were compared by Student's t tests. In post-hoc analyses to determine bioequivalence, least-squares mean ratios of percent change from baseline in plasma phospholipid and erythrocyte DHA levels were compared. DHA levels increased by ∼80% in plasma phospholipids and by ∼25% in erythrocytes in both groups. Changes in DHA levels in plasma phospholipids and erythrocytes were similar between groups. As measured by delivery of DHA to both plasma and erythrocytes, fish and algal-oil capsules were equivalent. Both regimens were generally well-tolerated. These results indicate that algal-oil DHA capsules and cooked salmon appear to be bioequivalent in providing DHA to plasma and red blood cells and, accordingly, that algal-oil DHA capsules represent a safe and convenient source of non–fish-derived DHA.
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      L. M. Arterburn is senior director, Pharmacology and Toxicology, Alba Therapeutics, Baltimore, MD; at the time of the study, she was director, Clinical Research, Martek Biosciences Corporation, Columbia, MD.


      H. A. Oken is clinical professor of medicine, University of Maryland, Baltimore.


      J. A. Hamersley is clinical study coordinator, Charter Medical Group, University of Maryland, Baltimore.


      E. Bailey Hall is laboratory manager, Clinical Research, C. N. Kuratko is principal scientist, medical affairs, and J. P. Hoffman is director of medical services, Martek Biosciences Corporation, Columbia, MD.