Abstract
The profession of dietetics can take an increasingly prominent role in managing health
and patient care as clinicians gain access to three new resources: detailed information
about the metabolic status of healthy individual clients, metabolic knowledge about
the relationships between metabolite abundances and health, and bioinformatics tools
that link clients’ metabolism to their present and future health status. The current
use of single biomarkers as indicators of disease will be replaced by comprehensive
profiling of individual metabolites linked to an understanding of health and human
metabolism—the emerging science now known as metabolomics. Industrial and academic
initiatives are currently developing the analytical and bioinformatic technologies
needed to assemble the quantitative reference databases of metabolites as the metabolic
analog of the human genome. With these in place, dietetics professionals will be able
to assess both the current health status of individuals and predict their health trajectories.
Another important role for dietetics professionals will be to assist in the development
of the tools and their application in predicting how an individual’s specific metabolic
pattern can be changed by diet, drugs, and lifestyle, with the goal of improving health
and preventing the development of chronic diseases.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Academy of Nutrition and DieteticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- What your genes want you to eat—The new science of nutrigenomics wants to create the ultimate personal menu.New York Times Magazine. 2003; 4: 6-7
- Individualized nutritional recommendations.Proc Nutr Soc. 2004; 63: 167-172
- Committee on the Management of Patients with Chronic Stable Angina. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—Summary article.Circulation. 2003; 107: 149-158
- National Cholesterol Education Program (NCEP)—The National Cholesterol Guidelines in 2001, Adult Treatment Panel (ATP) III. Approach to lipoprotein management in 2001 National Cholesterol Guidelines.Am J Cardiol. 2002; 90: S11-S21
- Chemical, pharmacokinetic and pharmacodynamic properties of statins.Fundam Clin Pharmacol. 2005; 19: 117-125
- Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease.Ann Intern Med. 2004; 141: 764-770
- Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone.J Lipid Res. 2002; 43: 1809-1817
- Protein and amino acids.Asia Pac J Clin Nutr. 2004; 13: S12
- Nutrigenomics.Curr Opin Biotechnol. 2002; 13: 517-521
- Towards a systems biology understanding of human health.Biotechnol Annu Rev. 2004; 10: 51-84
- Proteomics.J Nutr. 2003; 133: S2090-S2096
- From genomics to proteomics.Nature. 2003; 422: 193-197
- Metabolite profiling for plant functional genomics.Nat Biotechnol. 2000; 18: 1157-1161
- Metabonomics.Xenobiotica. 1999; 29: 1181-1189
- Metabonomics.Curr Opin Mol Ther. 2004; 6: 265-272
- Metabolomics.Environ Health Perspect. 2004; 112: A410-A415
- Differential response to low-fat diet between low and normal HDL-cholesterol subjects.J Lipid Res. 2000; 41: 321-328
- Carbohydrate-induced hypertriacylglycerolemia.Am J Clin Nutr. 2000; 71: 412-433
- Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs.J Nutr. 2003; 13: 1776-1780
- Metabolomics in systems biology.Annu Rev Plant Biol. 2003; 54: 669-689
- Systems biology.Mech Aging Dev. 2003; 124: 9-16
- Metabolomics in the opening decade of the 21st century.J Nutr. 2004; 134: 2729-2732
- Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice.J Nutr. 2003; 133: 3386-3391
- Individual metabolism should guide agriculture toward foods for improved health and nutrition.Am J Clin Nutr. 2001; 74: 283-286
- Metabolic networks of Cucurbita maxima phloem.Phytochemistry. 2003; 62: 875-886
- A vision for the future of genomics research.Nature. 2003; 422: 835-847
- Opinion: Understanding ‘global’ systems biology: Metabonomics and the continuum of metabolism.Nat Rev Drug Discov. 2003; 2: 668-676
- Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics.Nat Med. 2002; 8: 1439-1444
- The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLCMS/MS.J Lipid Res. 2002; 43: 1563-1578
- Rapid identification of stress-related fingerprint from whole bacterial cells of Bifidobacterium lactis using matrix assisted laser desorption/ionization mass spectrometry.J Am Soc Mass Spectrom. 2004; 15: 1222-1227
National Institutes of Health. NIH Roadmap Initiatives 2004: Accelerating medical discovery to improve health. Available at: http://nihroadmap.nih.gov. Accessed Feb 14, 2005.
- Metabolomics.Br J Nutr. 2004; 92: 549-555
- Diet, nutrition and cancer prevention.J Nutr. 2003; 133: S3830-S3836
- Incorporating basic nutrition science into health interventions for cancer prevention.J Nutr. 2003; 133: S3820-S3826
- Genomics and metabolomics as markers for the interaction of diet and health.J Nutr. 2003; 133: S2078-S2083
- Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile.Anal Biochem. 2003; 323: 197-204
- Ethyl glucoside in human urine following dietary exposure.Analyst. 2004; 129: 259-264
- Personal metabolomics as a next generation nutritional assessment.J Nutr. 2003; 133: 4260-4266
Biography
J. B. German is a professor with the Department of Food Science and Technology, University of California, Davis. J. B. German is scientific advisor and L.-B. Fay is department head, Nestlé Research Center, Lausanne, Switzerland. S. M. Watkins is president and chief scientific officer, Lipomics Technologies, Inc, West Sacramento, CA.
Article info
Identification
Copyright
© 2005 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
