The dietetics profession has been guided by advances in science that are translated
to clinical practice guidelines. Inherent to advancing practice is the ongoing scientific
dialogue. Progress made in clinical practice reflects the evolution of ideas and opinions
that are subjected to additional scientific experimentation to advance our understanding
and resolve “debates.” A good example of ongoing dialogue is the discussion about
n-6 polyunsaturated fatty acids (PUFAs) and heart health. The National Academies and
the Dietary Guidelines Advisory Committee 2005 have recommended that PUFAs provide
5% to 10% of energy (
1
,
2
). By comparison, the American Dietetic Association Fatty Acid Position paper advised
that PUFAs provide 3% to 10% of energy. Although linoleic acid (LA) has long been
recognized as an essential nutrient, the dialogue about how much LA to consume beyond
the requirement is based on the extent to which higher PUFA intakes have beneficial
or harmful effects. Proponents of the position that intake should be set at a level
no higher than that which prevents an essential fatty acid deficiency (around 1% to
2% of energy) assert that higher PUFA intakes have deleterious health effects and,
as a result, believe that n-6 PUFA intakes (and current dietary recommendations) should
be decreased. Advocates of a higher PUFA intake disagree, citing evidence for health
benefits with higher intakes. The purpose of this Commentary is to present these different
perspectives and to discuss the American Heart Association Science Advisory on n-6
PUFA that supports the current dietary recommendation of 5% to 10% of energy for heart
health.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Academy of Nutrition and DieteticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids.National Academies Press, Washington, DC2002 (National Academies Press Web site) (Accessed November 10, 2009)
- Dietary Guidelines for Americans: The Report of the Dietary Guidelines Advisory Committee on Dietary Guidelines for Americans, 2005.(US Department of Health and Human Services Web site) (Accessed November 10, 2009)
- Omega-6 fatty acids and risk for cardiovascular disease: A science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention.Circulation. 2009; 119: 902-907
- Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events.Atherosclerosis. 2007; 193: 1-10
- Major types of dietary fat and risk of coronary heart disease: A pooled analysis of 11 cohort studies.Am J Clin Nutr. 2009; 89: 1425-1432
- Omega-6 polyunsaturated fatty acids and coronary heart disease.Am J Clin Nutr. 2009; 89: 1283-1284
- Lowering cholesterol and total mortality.in: Rifkin B.M. Lowering Cholesterol in High-Risk Individuals and Populations. Marcel Dekker, Inc, New York, NY1995: 33-48
- Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials.Am J Clin Nutr. 2003; 77: 1146-1155
- The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.Exp Biol Med. 2008; 233: 674-688
- The Omega-3 Index: A new risk factor for death from coronary heart disease?.Prev Med. 2004; 39: 212-220
- Letter to the editor.Prostaglandins Leukot Essent Fatty Acids. 2009; 80: 77-79
- Letters to the Editor and writing group response regarding “Omega-6 fatty acids and risk for cardiovascular disease”—Letters submitted by Ramsden C, Hibbeln J, Lands B, and Tribole E.(American Heart Association Web site) (Accessed January 4, 2010)
- Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men.J Lipid Res. 2005; 46: 269-280
- Arachidonic acid cytochrome P450 epoxygenase pathway.J Lipid Res. 2009; 50: S52-S56
- Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution.Prostaglandins Leukot Essent Fatty Acids. 2005; 73: 141-162
- Too much linoleic acid promotes inflammation—Doesn't it?.Prostaglandins Leukot Essent Fatty Acids. 2008; 79: 173-175
- What We Eat in America, NHANES, 2005-2006, individuals 2 years and over (excluding breast-fed children), day 1 dietary intake data, weighted.(Accessed January 4, 2010)
- What We Eat in America, NHANES, 2005-2006, individuals 2 years and over (excluding breast-fed children), day 1 dietary intake data, weighted. US Department of Agriculture, Agricultural Research Service.(Accessed January 4, 2010)
- Diet and lifestyle recommendations revision 2006: A scientific statement from the American Heart Association Nutrition Committee.Circulation. 2006; 114 ([published online ahead of print June 19, 2006]): 82-96
Biography
P. Kris-Etherton is a distinguished professor of Nutrition, Department of Nutritional Sciences, Penn State University, University Park, PA
Biography
J. Fleming is clinical project coordinator, Department of Nutritional Sciences, Penn State University, University Park, PA
Biography
W. S. Harris is director of the Cardiovascular Health Research Center, Sanford Research/USD and Sanford School of Medicine, University of South Dakota, Sioux Falls, SD
Article info
Publication history
Accepted:
November 23,
2009
Identification
Copyright
© 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.