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Cholesterol-lowering effects of ready-to-eat cereal containing psyllium

      Since the National Cholesterol Education Program (NCEP) made its recommendations in 1988 (
      • National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol Adults
      Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults.
      ), much attention has been focused on nonpharmacologic methods of enhancing the cholesterol reduction achieved by following a prudent diet. Research has shown that soluble fiber lowers blood cholesterol levels and that oats, psyllium hydrophilic mucilloid, and psyllium-enriched cereal can enhance the cholesterol-lowering effects achieved with a prudent diet alone (
      • Lipsky H
      • Gloger M
      • Frishman WH
      Dietary fiber for reducing blood cholesterol.
      ,
      • Glassman M
      • Spark A
      • Berexin S
      • Schwartz S
      • Medow M
      • Newman LJ
      Treatment of type IIa hyperlipidemia in childhood by a simplified American Heart Association diet and fiber supplementation.
      ,
      • Judd PA
      • Truswell AS
      The effect of rolled oats on blood lipids and fecal steroid excretion in man.
      ,
      • Keys A
      • Grande F
      • Anderson JT
      Pectin in the diet and serum cholesterol concentrations in man.
      ,
      • Kirby RW
      • Anderson JW
      • Sieling B
      • Rees ED
      • Chen WL
      • Miller RE
      • Kay RM
      Oat brain intake selectively lowers serum low-density lipoprotein cholesterol concentrations of hypercho-lesterolemic men.
      ,
      • Truswell AS
      • Kay RM
      Absence of effect of bran on blood lipids.
      ,
      • Anderson JW
      • Story L
      • Sieling B
      • Chen WL
      • Petro MS
      • Story J
      Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men.
      ,
      • Gold K
      • Davidson DM
      Oat bran as a cholesterol-reducing dietary adjunct in a young, healthy population.
      ,
      • Danielsson A
      • Ek B
      • Nyhlin H
      • Steen L
      Effect of long-term treatment with hydrophilic colloid on serum lipids.
      ,
      • Garvin JE
      • Forman DT
      • Eiseman WR
      • Phillips CR
      Lowering of human serum cholesterol by an oral hydrophilic colloid.
      ,
      • Burton R
      • Manninen V
      Influence of a psyllium-based fiber preparation on faecal and serum parameters.
      ,
      • Fagerberg SE
      The effect of bulk laxative (Metamucil) on fasting blood glucose, serum lipids and other variables in constipated patients with non-insulin dependent adult diabetes.
      ,
      • Lieberthal MM
      • Marten RA
      Lowered serum cholesterol following the ingestion of a hydrophilic colloid.
      ,
      • Anderson JW
      • Zettwoch N
      • Feldman T
      • Tietyen-Clark J
      • Oeltgen P
      • Bishop CW
      Cholesterol lowering effects of psyllium hydrophillic mucilloid for hypercholesterolemic men.
      ,
      • Bell LP
      • Hectorne K
      • Reynolds H
      • Balm TK
      • Hunninghake DB
      Cholesterol lowering effect of psyllium hydrophilic mucilloid.
      ,
      • Neal GW
      • Balm TK
      Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia.
      ,
      • Levin CG
      • Miller VT
      • Muesing RA
      • Stoy DB
      • Balm TK
      • LaRosa JC
      Comparison of psyllium hydrophilic mucilloid and cellulose as adjuncts to a prudent diet in the treatment of mild to moderate hypercholesterolemia.
      ,
      • Anderson JW
      • Riddell-Mason S
      • Gustafson NJ
      • Smith SF
      • Mackay M
      Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia.
      ,
      • Ripsen CM
      • Keenan JM
      • Jacobs DR
      • Elmer PJ
      • Welch RR
      • Van Horn L
      • Liu K
      • Turnbull WH
      • Thye FW
      • Kestin M
      • Hegsted M
      • Davidson DM
      • Davidson MH
      • Dugan LD
      • Demark-Wahnefried W
      • Beling S
      Oat products and lipid lowering.
      ).
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        The effect of rolled oats on blood lipids and fecal steroid excretion in man.
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        Pectin in the diet and serum cholesterol concentrations in man.
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        Oat brain intake selectively lowers serum low-density lipoprotein cholesterol concentrations of hypercho-lesterolemic men.
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